Eukaryotic Single-Cell Genomics

The Eukaryotic Single-Cell Genomics is a facility under SciLifeLab.

The Eukaryotic Single-Cell Genomics (ESCG) facility, aims at providing single cell transcriptomics and genomics services to the scientific community. Single cell analysis is an emerging technology that allows for the exploration of the transcriptome and genome content of individual cells. The facility offers streamlined single cell RNA sequencing, as well as whole genome DNA amplification to the scientific community, in Sweden and beyond.

Applications

Here is a list of potential applications that you could use our facility for:

  • Study heterogeneity within putatively homogenous cell populations
  • Unbiased discovery of cell types in complex tissues
  • Characterizing the cellular and genetic composition of tumors

 

Publications

  • Marques, S., van Bruggen, D., Vanichkina, D.P., Floriddia, E.M., Munguba, H., Väremo, L., Giacomello, S., Falcão, A.M., Meijer, M., Björklund, Å.K. and Hjerling-Leffler, J., 2018. Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development. Developmental cell46(4), pp.504-517. PMID: 30078729
  • Furlan, A., Dyachuk, V., Kastriti, M.E., Calvo-Enrique, L., Abdo, H., Hadjab, S., Chontorotzea, T., Akkuratova, N., Usoskin, D., Kamenev, D. and Petersen, J., 2017. Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. Science357(6346), p.eaal3753. PMID: 28684471
  • Petitpré, C., Wu, H., Sharma, A., Tokarska, A., Fontanet, P., Wang, Y., Helmbacher, F., Yackle, K., Silberberg, G., Hadjab, S. and Lallemend, F., 2018. Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nature communications9(1), p.3691. PMID: 30209249

 

Feel free to contact us to discuss about your project.